BRCA1-mediated repression of select X chromosome genes

BRCA1-mediated repression of select X chromosome genes

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Abstract Release Lever Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome.In this study the influence of BRCA1 on expression of X chromosome genes was investigated.Complementary DNA microarrays were used to compare the expression levels of X chromosome genes in 18 BRCA1-associated ovarian cancers Kitchen Caddy to those of the 13 "BRCA1-like" and 14 "BRCA2-like" sporadic tumors (as defined by previously reported expression profiling).Significance was determined using parametric statistics with P.